Healthy Baby. Healthy Mother.

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Healthy Baby. Healthy Mother.

Every patient’s goal is to conceive a happy and healthy child. For some patients and couples, assistance up to and including IVF is necessary. One of the biggest concerns for couples thinking about IVF is the multiple pregnancy rate. While many IVF programs are striving to reduce triplet pregnancy rates, even twin pregnancies increase maternal and fetal risk. While over 90% percent of twin pregnancies that progress to term do well (term is considered to be 37 weeks), nearly 60% of twins deliver before 37 weeks and 11 percent deliver before 32 weeks. The risks to the baby of premature delivery include respiratory distress, gastrointestinal infections, and even intracranial bleeding requiring extended admission to a neonatal intensive care unit. There are increased risks of developmental delay even in deliveries that occur between 32-36 weeks of gestation.

Twin pregnancies also carry increased maternal risks, including a twofold increase in pregnancy-induced hypertension, gestational diabetes, and hospital admission prior to delivery. The complication risk at the time of delivery is also increased, as evidenced by the two to threefold increased risk of Cesarean section and increased likelihood of postpartum hemorrhage. Since multiple gestations so commonly result in complications for the mothers and babies, patients often consult with high-risk OB doctors called maternal fetal medicine physicians. Despite vigilance on the part of the obstetrician and the MFM doctors, there are some risks inherent to the twin pregnancy itself that cannot always be avoided.

With recent advances in embryo culture, comprehensive chromosomal screening (CCS) of embryos and improved medical therapy in the practice of IVF, high pregnancy rates can be achieved with single embryo transfer (SET). Reproductive Medicine Associates of New York is one of the leading practices in the country to offer state-of-the-art single embryo transfer utilizing comprehensive chromosomal screening. We are able to identify healthy, chromosomally normal embryos with greater than 98% accuracy. By selecting a single optimal embryo to achieve higher implantation rates, we are able to improve pregnancy rates while minimizing pregnancy losses and increasing the likelihood of a safe full-term delivery. Also, by applying the latest freezing technology (known as vitrification) we are able to cryopreserve healthy embryos for future pregnancies in many cases. Reproductive Medicine Associates of New York is committed to offering this technology to couples in an effort to not only improve pregnancy rates but also improve outcomes for mother and baby.

embryo

Single embryo transfer (SET) experience at RMANY

IVF with CCS may also benefit women 35 years or older who experience repeated pregnancy loss and recurrent IVF failure. While healthy embryos have 46 chromosomes, over 60% of miscarriages and the failure of many in vitro fertilization (IVF) cycles are a result of aneuploidy, a condition in which an embryo has either too many or too few chromosomes. Comprehensive Chromosomal Screening (CCS) is a highly advanced technology utilizing the polymerase chain reaction (PCR) to safely and effectively screen embryos. When combined with Single Embryo Transfer (SET), it avoids the complications often associated with twin or multiple pregnancies and deliveries. CCS is one of the latest and most successful technologies available for patients age 35 or older with multiple failed in vitro fertilization (IVF) cycles or miscarriages.

 

Chromosome Screening No Screening
Number of Embryos Transferred

1 (known as SET – Single Embryo Transfer)

2 (known as DET – Dual Embryo Transfer)

1 (Single Embryo Transfer)

2 (Dual Embryo Transfer)

Sample Size (n) n=210 n=101 n=667 n=2282
Clinical Preg 58.1% (n=122)
122/210
62.4% (n=63)
63/101
32.8% (n=219)
219/667
58.8% (n=1342)
1342/2282
Live Birth 48.6% (n=102)
102/210
47.5% (n=48)
48/101
24.4% (n=163)
163/667
50.4% (n=1150)
1150/2282
Multiple Preg 2.4% (n=5)
5/210
17.8% (n=18)
18/101
0.3% (n=2)
2/667
16.3% (n=341)
341/2282

Data taken from ET Dates 1/8/2008 – 12/18/2013*

*A comparison of clinic success rates may not be meaningful because patient medical characteristics, treatment approaches and entrance criteria for ART may vary from clinic to clinic.  Patients of all ages were included in the above data.

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