Implantation failure is a commonly cited cause of infertility. Some causes of implantation failure include uterine anomalies, male factor infertility, and embryonic factors, such as chromosomal abnormalities, genetic mutations, or factors associated with energy production and stress response. Pre-implantation genetic testing (PGT) has improved live birth rates and reduced miscarriage rates remarkably, but physicians are still trying to understand why some chromosomally screened embryos fail to implant. Mitochondria, which are the primary energy source of cells, have been suggested to play a role in embryonic competence.

August 19, 2019